The Poison Rune is an item used primarily as ammunition for staves.
Using Unpowered Runes or Charged Runes on a Rune Shrine that is centered on a Poison Rune Shrine, will convert those Runes into Poison Runes. The player can only convert Runes into Poison Runes if their Runation level is 22 or higher.
Poison Runes can be obtained as a drop from the following mobs:
Poison Runes can be found when opening a Rune Box.
Poison Runes are required as ammunition for the following Staves:
Additionally, Runic Sword can consume Poison Runes when attacking to poison mobs on hit.
|Poison Staff||1 Poison Rune +
|Spraggy Slab||1 Draggy Slab +
1 Poison Rune +
1 Blank Slab